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Oral diabetes medicines help control blood glucose levels in people whose bodies still produce some insulin. The following are various categories of oral medicines listed by medication classifications and how the medicines work.

Oral diabetes medicines (taken by mouth) help control blood sugar (glucose) levels in people whose bodies still produce some insulin, such as some people with type 2 diabetes. These medicines are prescribed along with regular exercise and changes in the diet. Many oral diabetes medications may be used in combination with each other or with insulin to achieve the best blood glucose control.

This guide provides general information about the different oral medicines for diabetes. It will help you learn more about your medication. Always take your medicine exactly as your doctor prescribes it. Discuss your specific questions and concerns with your health care provider.

Sulfonylureas

Glipizide (Glucotrol®, Glucotrol XL®,), Glimepride (Amaryl®), Glyburide (DiaBeta®, Glynase PresTab®, Micronase®)

These medications lower blood glucose by causing the pancreas to release more insulin.

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Metformin (Glucophage®, Glucophage XR®, Glumetza®, Fortamet®, Riomet®)

These medications reduce how much glucose the liver produces. It also improves how insulin works in the body, and slows down the conversion of carbohydrates into sugar.

Thiazolidinediones

Pioglitozone (Actos®), rosiglitozone (Avandia®)

These medications improve the way insulin works in the body by allowing more glucose to enter into muscles, fat, and the liver.

Alpha-glucosidase inhibitors

Acarbose (Precose®,) miglitol (Glyset®)

These medications lower blood glucose by delaying the breakdown of carbohydrates and reducing glucose absorption in the small intestine. They also block certain enzymes in order to the 1 last update 04 Aug 2020 slow down the digestion of some starches.These medications lower blood glucose by delaying the breakdown of carbohydrates and reducing glucose absorption in the small intestine. They also block certain enzymes in order to slow down the digestion of some starches.

Meglitinide

Repaglinide (Prandin®), nateglinide (Starlix®)

These medications the 1 last update 04 Aug 2020 lower blood glucose by getting the pancreas to release more insulin.These medications lower blood glucose by getting the pancreas to release more insulin.

DPP-4 inhibitors

Sitagliptin (Januvia®), saxagliptin (Onglyza®), linagliptin (Tradjenta®), alogliptin (Nesina®)

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SGLT2 inhibitors

Canagliflozin (Invokana®), dapagliflozin (Farxiga®), empagliflozin (Jardiance®)

These drugs work on the kidneys to remove extra sugar from the body.

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Colesevelam (Welchol®)

Bile acid sequestrants lower cholesterol and blood sugar levels in patients who have diabetes.

Dopamine agonist

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This medication lowers the amount of glucose released by the liver.

Last reviewed by a Cleveland Clinic medical professional on 05/04/2016.

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